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Dynamic coupling of residues within proteins as a mechanistic foundation of many enigmatic pathogenic missense variants
Many pathogenic missense mutations are found in protein positions that are neither well-conserved nor fall in any known functional domains. Consequently, we lack any mechanistic underpinning of dysfunction caused by such mutations. We explored the disruption of allosteric dynamic coupling between th...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017885/ https://www.ncbi.nlm.nih.gov/pubmed/35389981 http://dx.doi.org/10.1371/journal.pcbi.1010006 |