Cargando…

Antiretroviral drug exposure in lymph nodes is heterogeneous and drug dependent

INTRODUCTION: HIV reservoirs and infected cells may persist in tissues with low concentrations of antiretrovirals (ARVs). Traditional pharmacology methods cannot assess variability in ARV concentrations within morphologically complex tissues, such as lymph nodes (LNs). We evaluated the distribution...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosen, Elias P., Deleage, Claire, White, Nicole, Sykes, Craig, Brands, Catherine, Adamson, Lourdes, Luciw, Paul, Estes, Jacob D., Kashuba, Angela D. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018350/ https://www.ncbi.nlm.nih.gov/pubmed/35441468 http://dx.doi.org/10.1002/jia2.25895

Ejemplares similares

Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species
por: Thompson, Corbin G., et al.
Publicado: (2019)

Viral dissemination and immune activation modulate antiretroviral drug levels in lymph nodes of SIV-infected rhesus macaques
por: Srinivasula, Sharat, et al.
Publicado: (2023)

Viral Decay Kinetics in the Highly Active Antiretroviral Therapy-Treated Rhesus Macaque Model of AIDS
por: Deere, Jesse D., et al.
Publicado: (2010)

Programmable multistage drug delivery to lymph nodes
por: Schudel, Alex, et al.
Publicado: (2020)

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes
por: Watson, Dionysios C., et al.
Publicado: (2018)

Correction: Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes
por: Watson, Dionysios C., et al.
Publicado: (2018)

AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques
por: Dashti, Amir, et al.
Publicado: (2023)

Predicting Efavirenz Concentrations in the Brain Tissue of HIV‐Infected Individuals and Exploring their Relationship to Neurocognitive Impairment
por: Srinivas, Nithya, et al.
Publicado: (2019)

Drug Allergy and the Risk of Lymph Node Metastasis in Rectal Cancer
por: Gao, Chun, et al.
Publicado: (2014)

Lymph node macrophages: drug-related reaction or infectious-lesion?
por: Handra-Luca, Adriana
Publicado: (2018)

Nanomaterial-Based Drug Delivery System Targeting Lymph Nodes
por: Cheng, Zesheng, et al.
Publicado: (2022)

Establishing Novel Antiretroviral Imaging for Hair to Elucidate Nonadherence: Protocol for a Single-Arm Cross-sectional Study
por: Poliseno, Amanda, et al.
Publicado: (2023)

Antipolysaccharide antibodies of restricted heterogeneity secreted by a single lymph node
por: Frost, H, et al.
Publicado: (1976)

Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance
por: Kirwan, Daniela E., et al.
Publicado: (2016)

Multi-Compartment Lymph-Node-on-a-Chip Enables Measurement of Immune Cell Motility in Response to Drugs
por: Hallfors, Nicholas, et al.
Publicado: (2021)

HIV DNA persists in hepatocytes in people with HIV-hepatitis B co-infection on antiretroviral therapy
por: Zerbato, Jennifer M., et al.
Publicado: (2022)

Subcostal lymph nodes: An unusual sentinel lymph node basin in cutaneous melanoma
por: Marsh, Katherine M., et al.
Publicado: (2022)

Molecular Heterogeneity in Primary Breast Carcinomas and Axillary Lymph Node Metastases Assessed by Genomic Fingerprinting Analysis
por: Ellsworth, Rachel E, et al.
Publicado: (2015)

Evaluation of the Pharmacokinetics of Intranasal Drug Delivery for Targeting Cervical Lymph Nodes in Rats
por: Furubayashi, Tomoyuki, et al.
Publicado: (2021)

Next-generation in situ hybridization approaches to define and quantify HIV and SIV reservoirs in tissue microenvironments
por: Deleage, Claire, et al.
Publicado: (2018)

Feline Respiratory Extramedullary Plasmacytoma with Lymph Node Metastasis and Intrahistiocytic Amyloid
por: Sykes, S.E., et al.
Publicado: (2017)

Lymph Node Disorders
por: Qureshi, Faisal G., et al.
Publicado: (2012)

Antiretroviral Therapy for Prevention of HIV Infection: New Clues From an Animal Model
por: Cohen, Myron S, et al.
Publicado: (2008)

Drug concentrations in axillary lymph nodes after lymphatic chemotherapy on patients with breast cancer
por: Chen, Jianghao, et al.
Publicado: (2004)

New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery
por: Qi, Yangzhi, et al.
Publicado: (2023)

Molecular signatures of lymph node status by intrinsic subtype: gene expression analysis of primary breast tumors from patients with and without metastatic lymph nodes
por: Shriver, Craig D, et al.
Publicado: (2014)

Lymph nodes—The neglected battlefield in tuberculosis
por: Ganchua, Sharie Keanne C., et al.
Publicado: (2020)

Intranodal pressure of a metastatic lymph node reflects the response to lymphatic drug delivery system
por: Kato, Shigeki, et al.
Publicado: (2020)

YB-1 Expression Is Associated with Lymph Node Metastasis and Drug Resistance to Adriamycin in Breast Cancer
por: Dong, Hanzhi, et al.
Publicado: (2023)

Kaposi Sarcoma of Lymph Nodes
por: Bhana, D., et al.
Publicado: (1970)

Size of Metastatic Lymph Nodes
por: Uriev, L., et al.
Publicado: (2013)

Lymphocyte–HEV Interactions in Lymph Nodes of a Sulfotransferase-deficient Mouse
por: van Zante, Annemieke, et al.
Publicado: (2003)

Immune heterogeneity of head and tail pancreatic lymph nodes in non-obese diabetic mice
por: Li, Xiaofei, et al.
Publicado: (2019)

Biomarker heterogeneity between primary breast cancer and synchronous axillary lymph node metastases
por: Xi, Xun, et al.
Publicado: (2020)

Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma
por: Kraft, John C., et al.
Publicado: (2017)

Should the left gastric artery lymph node be considered as the predictive lymph node for extra-gastric lymph node metastases?
por: Sun, Weilin, et al.
Publicado: (2020)

Ultra-long-acting removable drug delivery system for HIV treatment and prevention
por: Kovarova, Martina, et al.
Publicado: (2018)

Lymph node density as a surrogate marker for positive lymph nodes
por: Van Gorp, T, et al.
Publicado: (2011)

Sentinel Lymph Node Biopsy and Complete Lymph Node Dissection for Melanoma
por: Falk Delgado, Alberto, et al.
Publicado: (2019)

Targeting Lymph Node Sinus Macrophages to Inhibit Lymph Node Metastasis
por: Hu, Junqing, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vhper3h661f75tu2aq5iulnsj3