Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons

There are no effective cures for upper motor neuron (UMN) diseases, such as amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, and hereditary spastic paraplegia. Here, we show UMN loss occurs independent of spinal motor neuron degeneration and that UMNs are indeed effective cellular tar...

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Detalles Bibliográficos
Autores principales: Genç, Barış, Jara, Javier H., Sanchez, Santana S., Lagrimas, Amiko K. B., Gozutok, Oge, Kocak, Nuran, Zhu, Yongling, Özdinler, P. Hande
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018479/
https://www.ncbi.nlm.nih.gov/pubmed/34853443
http://dx.doi.org/10.1038/s41434-021-00303-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018479/
https://www.ncbi.nlm.nih.gov/pubmed/34853443
http://dx.doi.org/10.1038/s41434-021-00303-4

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