Characterizing piggyBat—a transposase for genetic modification of T cells

Chimeric antigen receptor (CAR) T cells targeting CD19 have demonstrated remarkable efficacy in the treatment of B cell malignancies. Current CAR T cell manufacturing protocols are complex and costly due to their reliance on viral vectors. Non-viral systems of genetic modification, such as with tran...

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Detalles Bibliográficos
Autores principales: Sutrave, Gaurav, Xu, Ning, Tang, Tiffany C.Y., Dolnikov, Alla, Gloss, Brian, Gottlieb, David J., Micklethwaite, Kenneth P., Gowrishankar, Kavitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018555/
https://www.ncbi.nlm.nih.gov/pubmed/35474955
http://dx.doi.org/10.1016/j.omtm.2022.03.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018555/
https://www.ncbi.nlm.nih.gov/pubmed/35474955
http://dx.doi.org/10.1016/j.omtm.2022.03.012

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