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Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population

The heterogeneous nature of human CD34(+) hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell RNA-sequencing and extensive xenotransplantation, we have un...

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Detalles Bibliográficos
Autores principales: Anjos-Afonso, Fernando, Buettner, Florian, Mian, Syed A., Rhys, Hefin, Perez-Lloret, Jimena, Garcia-Albornoz, Manuel, Rastogi, Namrata, Ariza-McNaughton, Linda, Bonnet, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018830/
https://www.ncbi.nlm.nih.gov/pubmed/35440586
http://dx.doi.org/10.1038/s41467-022-29675-w