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NOX activation in reactive astrocytes regulates astrocytic LCN2 expression and neurodegeneration

Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse cellular processes including cell death/survival, inflammation, iron delivery and cell differentiation. Elevated levels of LCN2 are considered as a biomarker of brain injury, however, the underlying regulatory me...

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Detalles Bibliográficos
Autores principales: Liu, Ruijia, Wang, Jun, Chen, Yang, Collier, Jenelle M., Capuk, Okan, Jin, Shijie, Sun, Ming, Mondal, Sujan K., Whiteside, Theresa L., Stolz, Donna B., Yang, Yongjie, Begum, Gulnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018876/
https://www.ncbi.nlm.nih.gov/pubmed/35440572
http://dx.doi.org/10.1038/s41419-022-04831-8