A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrid accumulation

Transcriptionally active loci are particularly prone to breakage and mounting evidence suggests that DNA Double-Strand Breaks arising in active genes are handled by a dedicated repair pathway, Transcription-Coupled DSB Repair (TC-DSBR), that entails R-loop accumulation and dissolution. Here, we unco...

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Detalles Bibliográficos
Autores principales: Cohen, S., Guenolé, A., Lazar, I., Marnef, A., Clouaire, T., Vernekar, D. V., Puget, N., Rocher, V., Arnould, C., Aguirrebengoa, M., Genais, M., Firmin, N., Shamanna, R. A., Mourad, R., Bohr, V. A., Borde, V., Legube, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019021/
https://www.ncbi.nlm.nih.gov/pubmed/35440629
http://dx.doi.org/10.1038/s41467-022-29629-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019021/
https://www.ncbi.nlm.nih.gov/pubmed/35440629
http://dx.doi.org/10.1038/s41467-022-29629-2

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