Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors

The AKT kinases have emerged as promising therapeutic targets in oncology and both allosteric and ATP-competitive AKT inhibitors have entered clinical investigation. However, long-term efficacy of such inhibitors will likely be challenged by the development of resistance. We have established prostat...

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Detalles Bibliográficos
Autores principales: Savill, Kristin M. Zimmerman, Lee, Brian B., Oeh, Jason, Lin, Jie, Lin, Eva, Chung, Wei-Jen, Young, Amy, Chen, Wennie, Miś, Monika, Mesh, Kathryn, Eastham, Jeffrey, Gnad, Florian, Jiang, Zhaoshi, Stawiski, Eric W., Haley, Benjamin, Daemen, Anneleen, Wang, Xiaojing, Koeppen, Hartmut, Modrusan, Zora, Martin, Scott E., Sampath, Deepak, Lin, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019088/
https://www.ncbi.nlm.nih.gov/pubmed/35440108
http://dx.doi.org/10.1038/s41467-022-29655-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019088/
https://www.ncbi.nlm.nih.gov/pubmed/35440108
http://dx.doi.org/10.1038/s41467-022-29655-0

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