Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation

The gene regulation underlying axon formation and its exclusiveness to neurons remains elusive. TRIM46 is postulated to determine axonal fate. We show Trim46 mRNA is expressed before axonogenesis, but TRIM46 protein level is inhibited by alternative splicing of two cassette exons coupled separately...

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Detalles Bibliográficos
Autores principales: Vuong, John K., Ergin, Volkan, Chen, Liang, Zheng, Sika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019110/
https://www.ncbi.nlm.nih.gov/pubmed/35440129
http://dx.doi.org/10.1038/s41467-022-29786-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019110/
https://www.ncbi.nlm.nih.gov/pubmed/35440129
http://dx.doi.org/10.1038/s41467-022-29786-4

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