SHP2 Inhibitors Show Anti-Myeloma Activity and Synergize With Bortezomib in the Treatment of Multiple Myeloma

Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. The protein tyrosine phosphatase SHP2 is a central node regulating RAS/mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase (ERK) signaling pathway which plays a crucial role in the pathogenesis and pr...

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Detalles Bibliográficos
Autores principales: Zhou, Pan, Xiao, Mengyu, Li, Weiya, Sun, Xiaobai, Bai, Yanliang, Meng, Feiying, Zhu, Zunmin, Yuan, Weiping, Sun, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019471/
https://www.ncbi.nlm.nih.gov/pubmed/35462913
http://dx.doi.org/10.3389/fphar.2022.841308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019471/
https://www.ncbi.nlm.nih.gov/pubmed/35462913
http://dx.doi.org/10.3389/fphar.2022.841308

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