OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts

Dysfunctional missense variant of organic anion transporter 10 (OAT10/SLC22A13), rs117371763 (c.1129C>T; p.R377C), is associated with a lower susceptibility to gout. OAT10 is a urate transporter; however, its physiological role in urate handling remains unclear. We hypothesized that OAT10 could b...

Descripción completa

Detalles Bibliográficos
Autores principales: Toyoda, Yu, Kawamura, Yusuke, Nakayama, Akiyoshi, Morimoto, Keito, Shimizu, Seiko, Tanahashi, Yuki, Tamura, Takashi, Kondo, Takaaki, Kato, Yasufumi, Ichida, Kimiyoshi, Suzuki, Hiroshi, Shinomiya, Nariyoshi, Kobayashi, Yasushi, Takada, Tappei, Matsuo, Hirotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019507/
https://www.ncbi.nlm.nih.gov/pubmed/35462902
http://dx.doi.org/10.3389/fphar.2022.842717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019507/
https://www.ncbi.nlm.nih.gov/pubmed/35462902
http://dx.doi.org/10.3389/fphar.2022.842717

Ejemplares similares