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Dichotomous feedback: a signal sequestration-based feedback mechanism for biocontroller design

We introduce a new design framework for implementing negative feedback regulation in synthetic biology, which we term ‘dichotomous feedback’. Our approach is different from current methods, in that it sequesters existing fluxes in the process to be controlled, and in this way takes advantage of the...

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Detalles Bibliográficos
Autores principales: Sootla, Aivar, Delalez, Nicolas, Alexis, Emmanouil, Norman, Arthur, Steel, Harrison, Wadhams, George H., Papachristodoulou, Antonis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019519/
https://www.ncbi.nlm.nih.gov/pubmed/35440202
http://dx.doi.org/10.1098/rsif.2021.0737