Design, Synthesis, and Biological Evaluation of [1,2,4]triazolo[4,3-a] Pyrazine Derivatives as Novel Dual c-Met/VEGFR-2 Inhibitors

In this study, we designed and synthesized a series of novel [1,2,4]triazolo [4,3-a]pyrazine derivatives, and evaluated them for their inhibitory activities toward c-Met/VEGFR-2 kinases and antiproliferative activities against tested three cell lines in vitro. Most of the compounds showed satisfacto...

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Detalles Bibliográficos
Autores principales: Liu, Xiaobo, Li, Yuzhen, Zhang, Qian, Pan, Qingshan, Zheng, Pengwu, Dai, Xinyang, Bai, Zhaoshi, Zhu, Wufu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019572/
https://www.ncbi.nlm.nih.gov/pubmed/35464202
http://dx.doi.org/10.3389/fchem.2022.815534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019572/
https://www.ncbi.nlm.nih.gov/pubmed/35464202
http://dx.doi.org/10.3389/fchem.2022.815534

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