GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer’s Disease

Amyloid β (Aβ) and/or ATP activate the NLRP3 inflammasome (N3I) via P2X7R in microglia, which is crucial in neuroinflammation in Alzheimer’s disease (AD). Due to polymorphisms, subtypes, and ubiquitous expression of P2X7R, inhibition of P2X7R has not been effective for AD. We first report that tauro...

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Detalles Bibliográficos
Autores principales: Islam, Jahirul, Cho, Jung-Ah, Kim, Ju-yong, Park, Kyung-Sun, Koh, Young-Jae, Chung, Chu Young, Lee, Eun-Jae, Nam, Soo Jeong, Lee, Kyoungyul, Kim, Seoung-Heon, Park, Sung-Hye, Lee, Dong Young, Kim, Byeong C., Lee, Kyung-Hwa, Seong, Seung-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019633/
https://www.ncbi.nlm.nih.gov/pubmed/35464490
http://dx.doi.org/10.3389/fimmu.2022.766919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019633/
https://www.ncbi.nlm.nih.gov/pubmed/35464490
http://dx.doi.org/10.3389/fimmu.2022.766919

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