Construction of a Large Size Human Immunoglobulin Heavy Chain Variable (VH) Domain Library, Isolation and Characterization of Novel Human Antibody VH Domains Targeting PD-L1 and CD22

Phage display is a well-established technology for in vitro selection of monoclonal antibodies (mAb), and more than 12 antibodies isolated from phage displayed libraries of different formats have been approved for therapy. We have constructed a large size (10^11) human antibody VH domain library bas...

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Detalles Bibliográficos
Autores principales: Sun, Zehua, Li, Wei, Mellors, John W., Orentas, Rimas, Dimitrov, Dimiter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019674/
https://www.ncbi.nlm.nih.gov/pubmed/35464476
http://dx.doi.org/10.3389/fimmu.2022.869825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019674/
https://www.ncbi.nlm.nih.gov/pubmed/35464476
http://dx.doi.org/10.3389/fimmu.2022.869825

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