Substrate Protein Interactions and Methylglyoxal Modifications Reduce the Aggregation Propensity of Human Alpha-A-Crystallin G98R Mutant

The G98R mutation in αA-crystallin is associated with presenile cataract development in humans. Previous studies have indicated that mutant proteins altered structure, decreased stability, increased oligomeric size, loss of chaperone-like activity, and susceptibility to proteolysis could be contribu...

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Detalles Bibliográficos
Autores principales: Santhoshkumar, Puttur, Sharma, Krishna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019814/
https://www.ncbi.nlm.nih.gov/pubmed/35463950
http://dx.doi.org/10.3389/fmolb.2022.875205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019814/
https://www.ncbi.nlm.nih.gov/pubmed/35463950
http://dx.doi.org/10.3389/fmolb.2022.875205

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