DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer

Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is upregulated in various human cancers, including colorectal cancer (CRC). This study focused on the inhibition of TRIP13‐induced CRC progression and signalling by DCZ0415, a small molecule targeting TRIP13. It de...

Descripción completa

Detalles Bibliográficos
Autores principales: Agarwal, Sumit, Afaq, Farrukh, Bajpai, Prachi, Kim, Hyung‐Gyoon, Elkholy, Amr, Behring, Michael, Chandrashekar, Darshan Shimoga, Diffalha, Sameer Al, Khushman, Moh’d, Sugandha, Shajan P., Varambally, Sooryanarayana, Manne, Upender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019876/
https://www.ncbi.nlm.nih.gov/pubmed/35194944
http://dx.doi.org/10.1002/1878-0261.13201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019876/
https://www.ncbi.nlm.nih.gov/pubmed/35194944
http://dx.doi.org/10.1002/1878-0261.13201

Ejemplares similares