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DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer

Thyroid receptor‐interacting protein 13 (TRIP13), a protein of the AAA‐ATPase family, is upregulated in various human cancers, including colorectal cancer (CRC). This study focused on the inhibition of TRIP13‐induced CRC progression and signalling by DCZ0415, a small molecule targeting TRIP13. It de...

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Detalles Bibliográficos
Autores principales:	Agarwal, Sumit, Afaq, Farrukh, Bajpai, Prachi, Kim, Hyung‐Gyoon, Elkholy, Amr, Behring, Michael, Chandrashekar, Darshan Shimoga, Diffalha, Sameer Al, Khushman, Moh’d, Sugandha, Shajan P., Varambally, Sooryanarayana, Manne, Upender
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019876/ https://www.ncbi.nlm.nih.gov/pubmed/35194944 http://dx.doi.org/10.1002/1878-0261.13201

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