The distribution and density of Huntingtin inclusions across the Huntington disease neocortex: regional correlations with Huntingtin repeat expansion independent of pathologic grade

Huntington disease is characterized by progressive neurodegeneration, especially of the striatum, and the presence of polyglutamine huntingtin (HTT) inclusions. Although HTT inclusions are most abundant in the neocortex, their neocortical distribution and density in relation to the extent of CAG rep...

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Detalles Bibliográficos
Autores principales: Hickman, Richard A., Faust, Phyllis L., Marder, Karen, Yamamoto, Ai, Vonsattel, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020040/
https://www.ncbi.nlm.nih.gov/pubmed/35440014
http://dx.doi.org/10.1186/s40478-022-01364-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020040/
https://www.ncbi.nlm.nih.gov/pubmed/35440014
http://dx.doi.org/10.1186/s40478-022-01364-1

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