Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2

SARS-CoV-2 engages with human cells through the binding of its Spike receptor-binding domain (S-RBD) to the receptor ACE2. Molecular blocking of this engagement represents a proven strategy to treat COVID-19. Here, we report a single-chain antibody (nanobody, DL4) isolated from immunized alpaca with...

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Detalles Bibliográficos
Autores principales: Li, Tingting, Zhou, Bingjie, Li, Yaning, Huang, Suqiong, Luo, Zhipu, Zhou, Yuanze, Lai, Yanling, Gautam, Anupriya, Bourgeau, Salome, Wang, Shurui, Bao, Juan, Tan, Jingquan, Lavillette, Dimitri, Li, Dianfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020654/
https://www.ncbi.nlm.nih.gov/pubmed/35460753
http://dx.doi.org/10.1016/j.ijbiomac.2022.04.096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020654/
https://www.ncbi.nlm.nih.gov/pubmed/35460753
http://dx.doi.org/10.1016/j.ijbiomac.2022.04.096

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