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Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2
SARS-CoV-2 engages with human cells through the binding of its Spike receptor-binding domain (S-RBD) to the receptor ACE2. Molecular blocking of this engagement represents a proven strategy to treat COVID-19. Here, we report a single-chain antibody (nanobody, DL4) isolated from immunized alpaca with...
Autores principales: | Li, Tingting, Zhou, Bingjie, Li, Yaning, Huang, Suqiong, Luo, Zhipu, Zhou, Yuanze, Lai, Yanling, Gautam, Anupriya, Bourgeau, Salome, Wang, Shurui, Bao, Juan, Tan, Jingquan, Lavillette, Dimitri, Li, Dianfan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020654/ https://www.ncbi.nlm.nih.gov/pubmed/35460753 http://dx.doi.org/10.1016/j.ijbiomac.2022.04.096 |
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