Epac1 activation by cAMP regulates cellular SUMOylation and promotes the formation of biomolecular condensates

Protein SUMOylation plays an essential role in maintaining cellular homeostasis when cells are under stress. However, precisely how SUMOylation is regulated, and a molecular mechanism linking cellular stress to SUMOylation, remains elusive. Here, we report that cAMP, a major stress-response second m...

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Detalles Bibliográficos
Autores principales: Yang, Wenli, Robichaux, William G., Mei, Fang C., Lin, Wei, Li, Li, Pan, Sheng, White, Mark A., Chen, Yuan, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020664/
https://www.ncbi.nlm.nih.gov/pubmed/35442725
http://dx.doi.org/10.1126/sciadv.abm2960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020664/
https://www.ncbi.nlm.nih.gov/pubmed/35442725
http://dx.doi.org/10.1126/sciadv.abm2960

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