Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by photoreceptor dysfunction and death. The insulin re...

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Detalles Bibliográficos
Autores principales: Sánchez-Cruz, Alonso, Hernández-Pinto, Alberto, Lillo, Concepción, Isiegas, Carolina, Marchena, Miguel, Lizasoain, Ignacio, Bosch, Fátima, de la Villa, Pedro, Hernández-Sánchez, Catalina, de la Rosa, Enrique J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021205/
https://www.ncbi.nlm.nih.gov/pubmed/35444190
http://dx.doi.org/10.1038/s41419-022-04839-0

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