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Optogenetic activation of the diaphragm

Impaired diaphragm activation is common in many neuromuscular diseases. We hypothesized that expressing photoreceptors in diaphragm myofibers would enable light stimulation to evoke functional diaphragm activity, similar to endogenous bursts. In a mouse model, adeno-associated virus (AAV) encoding c...

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Detalles Bibliográficos
Autores principales: Benevides, Ethan S., Sunshine, Michael D., Rana, Sabhya, Fuller, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021282/
https://www.ncbi.nlm.nih.gov/pubmed/35444167
http://dx.doi.org/10.1038/s41598-022-10240-w