Simultaneous Quantitation of Clevidipine and Its Active Metabolite H152/81 in Human Whole Blood by LC-MS/MS: Application to Bioequivalence Study

Clevidipine is an ultrashort-acting dihydropyridine calcium antagonist, which can control blood pressure accurately. It is necessary to develop a liquid chromatography–tandem mass spectrometry (LC-MS/MS) method to quantitate clevidipine and its active metabolite H152/81 for clinical pharmacokinetic...

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Detalles Bibliográficos
Autores principales: Li, Pengfei, Wu, Haitang, Zhao, Zhixia, Du, Ping, Xu, Haitong, Liu, Hongchuan, Zhou, Yu, Yu, Weiyue, Li, Hao, Liu, Lihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021437/
https://www.ncbi.nlm.nih.gov/pubmed/35464212
http://dx.doi.org/10.3389/fchem.2022.861952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021437/
https://www.ncbi.nlm.nih.gov/pubmed/35464212
http://dx.doi.org/10.3389/fchem.2022.861952

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