Assessment of porphyrogenicity of drugs and chemicals in selected hepatic cell culture models through a fluorescence‐based screening assay

Compounds that induce 5‐aminolevulinic acid [ALA] synthase‐1 and/or cytochromes P‐450 may induce acute porphyric attacks in patients with the acute hepatic porphyrias [AHPs]. Currently, there is no simple, robust model used to assess and predict the porphyrogenicity of drugs and chemicals. Our aim w...

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Detalles Bibliográficos
Autores principales: Ma, Christopher D., Van Horn, Cynthia G., Wan, Meimei, Bishop, Colin, Bonkovsky, Herbert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022196/
https://www.ncbi.nlm.nih.gov/pubmed/35445802
http://dx.doi.org/10.1002/prp2.951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022196/
https://www.ncbi.nlm.nih.gov/pubmed/35445802
http://dx.doi.org/10.1002/prp2.951

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