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circMAP3K4 regulates insulin resistance in trophoblast cells during gestational diabetes mellitus by modulating the miR-6795-5p/PTPN1 axis

BACKGROUND: Insulin resistance (IR) during gestational diabetes mellitus (GDM) has been linked to dysregulated insulin-PI3K/Akt pathway. A defective insulin-PI3K/Akt pathway and dysregulated circular RNA (circRNA) levels have been observed in the placentas of patients with GDM; however, the mechanis...

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Detalles Bibliográficos
Autores principales: Du, Runyu, Wu, Na, Bai, Yu, Tang, Lei, Li, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022258/
https://www.ncbi.nlm.nih.gov/pubmed/35449053
http://dx.doi.org/10.1186/s12967-022-03386-8