Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma

BACKGROUND: A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism remains largely unknown. We sought to investigate the genomic correlates of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhenghang, Wang, Xinyu, Xu, Yu, Li, Jian, Zhang, Xiaotian, Peng, Zhi, Hu, Yajie, Zhao, Xinya, Dong, Kun, Zhang, Bei, Gao, Chan, Zhao, Xiaochen, Chen, Hui, Cai, Jinping, Bai, Yuezong, Sun, Yu, Shen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022268/
https://www.ncbi.nlm.nih.gov/pubmed/35443723
http://dx.doi.org/10.1186/s12916-022-02327-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022268/
https://www.ncbi.nlm.nih.gov/pubmed/35443723
http://dx.doi.org/10.1186/s12916-022-02327-y

Ejemplares similares