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Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma

BACKGROUND: A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism remains largely unknown. We sought to investigate the genomic correlates of th...

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Detalles Bibliográficos
Autores principales:	Wang, Zhenghang, Wang, Xinyu, Xu, Yu, Li, Jian, Zhang, Xiaotian, Peng, Zhi, Hu, Yajie, Zhao, Xinya, Dong, Kun, Zhang, Bei, Gao, Chan, Zhao, Xiaochen, Chen, Hui, Cai, Jinping, Bai, Yuezong, Sun, Yu, Shen, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022268/ https://www.ncbi.nlm.nih.gov/pubmed/35443723 http://dx.doi.org/10.1186/s12916-022-02327-y

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