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LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation

BACKGROUND: Mesenchymal stem cell (MSC) senescence is a phenotype of aging. Long noncoding RNAs (lncRNAs) are emerging as potential key regulators of senescence. However, the role of lncRNAs in MSC senescence remains largely unknown. RESULTS: We performed transcriptome analysis in senescent human ad...

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Detalles Bibliográficos
Autores principales: Yang, Yanlei, Liu, Suying, He, Chengmei, Lv, Taibiao, Zeng, Liuting, Zhang, Fengchun, Chen, Hua, Zhao, Robert Chunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022335/
https://www.ncbi.nlm.nih.gov/pubmed/35449031
http://dx.doi.org/10.1186/s13578-022-00782-x