Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index

Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous studies reported that the Arg95Ter nonsense variant o...

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Detalles Bibliográficos
Autores principales: Gurtan, Allan, Dominy, John, Khalid, Shareef, Vong, Linh, Caplan, Shari, Currie, Treeve, Richards, Sean, Lamarche, Lindsey, Denning, Daniel, Shpektor, Diana, Gurinovich, Anastasia, Rasheed, Asif, Hameed, Shahid, Saeed, Subhan, Saleem, Imran, Jalal, Anjum, Abbas, Shahid, Sultana, Raffat, Rasheed, Syed Zahed, Memon, Fazal-ur-Rehman, Shah, Nabi, Ishaq, Mohammad, Khera, Amit V., Danesh, John, Frossard, Philippe, Saleheen, Danish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022822/
https://www.ncbi.nlm.nih.gov/pubmed/35381001
http://dx.doi.org/10.1371/journal.pgen.1010093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022822/
https://www.ncbi.nlm.nih.gov/pubmed/35381001
http://dx.doi.org/10.1371/journal.pgen.1010093

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