Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity

Comparing SARS-CoV-2 infection-induced gene expression signatures to drug treatment-induced gene expression signatures is a promising bioinformatic tool to repurpose existing drugs against SARS-CoV-2. The general hypothesis of signature-based drug repurposing is that drugs with inverse similarity to...

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Detalles Bibliográficos
Autores principales: Barsi, Szilvia, Papp, Henrietta, Valdeolivas, Alberto, Tóth, Dániel J., Kuczmog, Anett, Madai, Mónika, Hunyady, László, Várnai, Péter, Saez-Rodriguez, Julio, Jakab, Ferenc, Szalai, Bence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022874/
https://www.ncbi.nlm.nih.gov/pubmed/35404937
http://dx.doi.org/10.1371/journal.pcbi.1010021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022874/
https://www.ncbi.nlm.nih.gov/pubmed/35404937
http://dx.doi.org/10.1371/journal.pcbi.1010021

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