Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves binding of a phosphorylated ubiquitin (pUb), followed by phosphorylation of the Ubl domain in parkin, bot...

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Detalles Bibliográficos
Autores principales: Dunkerley, Karen M., Rintala-Dempsey, Anne C., Salzano, Giulia, Tadayon, Roya, Hadi, Dania, Barber, Kathryn R., Walden, Helen, Shaw, Gary S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Molecular Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022993/
https://www.ncbi.nlm.nih.gov/pubmed/35262643
http://dx.doi.org/10.1042/BCJ20210741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022993/
https://www.ncbi.nlm.nih.gov/pubmed/35262643
http://dx.doi.org/10.1042/BCJ20210741

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