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Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin
The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves binding of a phosphorylated ubiquitin (pUb), followed by phosphorylation of the Ubl domain in parkin, bot...
Autores principales: | Dunkerley, Karen M., Rintala-Dempsey, Anne C., Salzano, Giulia, Tadayon, Roya, Hadi, Dania, Barber, Kathryn R., Walden, Helen, Shaw, Gary S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022993/ https://www.ncbi.nlm.nih.gov/pubmed/35262643 http://dx.doi.org/10.1042/BCJ20210741 |
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