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α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif

How cellular functions are regulated through protein phosphorylation events that promote or inhibit protein–protein interactions (PPIs) is key to understanding regulatory molecular mechanisms. Whilst phosphorylation can orthosterically or allosterically influence protein recognition, phospho-driven...

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Detalles Bibliográficos
Autores principales: Batchelor, Matthew, Dawber, Robert S., Wilson, Andrew J., Bayliss, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022996/
https://www.ncbi.nlm.nih.gov/pubmed/35212726
http://dx.doi.org/10.1042/BCJ20210812