Mechanisms of substrate recognition and N(6)-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes

AlkB homologue 5 (ALKBH5) is a ferrous iron and 2-oxoglutarate dependent oxygenase that demethylates RNA N(6)-methyladenosine (m(6)A), a post-transcriptional RNA modification with an emerging set of regulatory roles. Along with the fat mass and obesity-associated protein (FTO), ALKBH5 is one of only...

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Detalles Bibliográficos
Autores principales: Kaur, Simranjeet, Tam, Nok Yin, McDonough, Michael A, Schofield, Christopher J, Aik, Wei Shen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023255/
https://www.ncbi.nlm.nih.gov/pubmed/35333330
http://dx.doi.org/10.1093/nar/gkac195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023255/
https://www.ncbi.nlm.nih.gov/pubmed/35333330
http://dx.doi.org/10.1093/nar/gkac195

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