Hydrogen-deuterium exchange mass spectrometry of Mtr4 with diverse RNAs reveals substrate-dependent dynamics and interfaces in the arch

Mtr4 is a eukaryotic RNA helicase required for RNA decay by the nuclear exosome. Previous studies have shown how RNA en route to the exosome threads through the highly conserved helicase core of Mtr4. Mtr4 also contains an arch domain, although details of potential interactions between the arch and...

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Detalles Bibliográficos
Autores principales: Zhang, Naifu, Olsen, Keith J, Ball, Darby, Johnson, Sean J, D’Arcy, Sheena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023267/
https://www.ncbi.nlm.nih.gov/pubmed/35380691
http://dx.doi.org/10.1093/nar/gkac170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023267/
https://www.ncbi.nlm.nih.gov/pubmed/35380691
http://dx.doi.org/10.1093/nar/gkac170

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