Cargando…

Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences

We report on higher-order G-quadruplex structures adopted by long promoter sequences obtained by an iterative integrated structural biology approach. Our approach uses quantitative biophysical tools (analytical ultracentrifugation, small-angle X-ray scattering, and circular dichroism spectroscopy) c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Monsen, Robert C, DeLeeuw, Lynn W, Dean, William L, Gray, Robert D, Chakravarthy, Srinivas, Hopkins, Jesse B, Chaires, Jonathan B, Trent, John O
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023277/ https://www.ncbi.nlm.nih.gov/pubmed/35325198 http://dx.doi.org/10.1093/nar/gkac182

Ejemplares similares

The hTERT core promoter forms three parallel G-quadruplexes
por: Monsen, Robert C, et al.
Publicado: (2020)

The solution structures of higher-order human telomere G-quadruplex multimers
por: Monsen, Robert C, et al.
Publicado: (2021)

Conformational profiling of a G-rich sequence within the c-KIT promoter
por: Rigo, Riccardo, et al.
Publicado: (2017)

Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex
por: Monsen, Robert C., et al.
Publicado: (2022)

Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter
por: Todd, Alan K., et al.
Publicado: (2007)

Structure of a 28.5 kDa duplex-embedded G-quadruplex system resolved to 7.4 Å resolution with cryo-EM
por: Monsen, Robert C, et al.
Publicado: (2023)

Human POT1 unfolds G-quadruplexes by conformational selection
por: Chaires, Jonathan B, et al.
Publicado: (2020)

Stability and kinetics of G-quadruplex structures
por: Lane, Andrew N., et al.
Publicado: (2008)

Flexibility and structural conservation in a c-KIT G-quadruplex
por: Wei, Dengguo, et al.
Publicado: (2015)

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter
por: Kuryavyi, Vitaly, et al.
Publicado: (2010)

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III(1) element: insights into biological relevance and parallel-stranded G-quadruplex stability
por: Mathad, Raveendra I., et al.
Publicado: (2011)

Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection
por: Buscaglia, Robert, et al.
Publicado: (2013)

G-quadruplex structure and stability illuminated by 2-aminopurine phasor plots
por: Buscaglia, Robert, et al.
Publicado: (2012)

Kinetics and mechanism of K(+)- and Na(+)-induced folding of models of human telomeric DNA into G-quadruplex structures
por: Gray, Robert D., et al.
Publicado: (2008)

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation
por: Wei, Dengguo, et al.
Publicado: (2012)

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes
por: Dickerhoff, Jonathan, et al.
Publicado: (2021)

Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex
por: Hao, Taisen, et al.
Publicado: (2016)

Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
por: Tong, Xiaotian, et al.
Publicado: (2011)

An Improved Model for the hTERT Promoter Quadruplex
por: Chaires, Jonathan B., et al.
Publicado: (2014)

Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence
por: Dailey, Magdalena M., et al.
Publicado: (2010)

Alternative DNA structure formation in the mutagenic human c-MYC promoter
por: del Mundo, Imee Marie A., et al.
Publicado: (2017)

c-kit2 G-quadruplex stabilized via a covalent probe: exploring G-quartet asymmetry
por: Peterková, Kateřina, et al.
Publicado: (2021)

Extended molecular dynamics of a c-kit promoter quadruplex
por: Islam, Barira, et al.
Publicado: (2015)

Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin
por: Tawani, Arpita, et al.
Publicado: (2017)

Quantitative Formation of Monomeric G‐Quadruplex DNA from Multimeric Structures of c‐Myc Promoter Sequence
por: Rauser, Valerie, et al.
Publicado: (2020)

POT1 stability and binding measured by fluorescence thermal shift assays
por: DeLeeuw, Lynn W., et al.
Publicado: (2021)

Structure of two G-quadruplexes in equilibrium in the KRAS promoter
por: Marquevielle, Julien, et al.
Publicado: (2020)

G-Quadruplexes in c-MYC Promoter as Targets for Cancer Therapy
por: Bahls, Bárbara, et al.
Publicado: (2023)

Sequence variant (CTAGGG)(n) in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad
por: Lim, Kah Wai, et al.
Publicado: (2009)

Stability of intramolecular quadruplexes: sequence effects in the central loop
por: Guédin, Aurore, et al.
Publicado: (2009)

G-quadruplex structure of an anti-proliferative DNA sequence
por: Do, Ngoc Quang, et al.
Publicado: (2017)

Higher-order G-quadruplexes in promoters are untapped drug targets
por: Monsen, Robert C.
Publicado: (2023)

G-quadruplex conformation and dynamics are determined by loop length and sequence
por: Tippana, Ramreddy, et al.
Publicado: (2014)

Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences
por: Gaynutdinov, Timur I., et al.
Publicado: (2008)

Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition
por: Liu, Wenting, et al.
Publicado: (2019)

Two-quartet kit* G-quadruplex is formed via double-stranded pre-folded structure
por: Kotar, Anita, et al.
Publicado: (2019)

Hinge like domain motion facilitates human RBMS1 protein binding to proto-oncogene c-myc promoter
por: Aggarwal, Priyanka, et al.
Publicado: (2021)

Investigation of the Interaction between Aloe vera Anthraquinone Metabolites and c-Myc and C-Kit G-Quadruplex DNA Structures
por: Dallavalle, Sabrina, et al.
Publicado: (2022)

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K(+): insights into loop interactions of the parallel G-quadruplexes
por: Agrawal, Prashansa, et al.
Publicado: (2013)

The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions
por: Hänsel, Robert, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_59kiidde0nm3g4qsl5l7rj4sfq