Telomerase RNA TERC and the PI3K-AKT pathway form a positive feedback loop to regulate cell proliferation independent of telomerase activity

The core catalytic unit of telomerase comprises telomerase reverse transcriptase (TERT) and telomerase RNA (TERC). Unlike TERT, which is predominantly expressed in cancer and stem cells, TERC is ubiquitously expressed in normal somatic cells without telomerase activity. However, the functions of TER...

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Detalles Bibliográficos
Autores principales: Wu, Shu, Ge, Yuanlong, Lin, Kaixuan, Liu, Qianqian, Zhou, Haoxian, Hu, Qian, Zhao, Yong, He, Weifeng, Ju, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023280/
https://www.ncbi.nlm.nih.gov/pubmed/35323972
http://dx.doi.org/10.1093/nar/gkac179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023280/
https://www.ncbi.nlm.nih.gov/pubmed/35323972
http://dx.doi.org/10.1093/nar/gkac179

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