ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination

An inability to repair DNA double-strand breaks (DSBs) threatens genome integrity and can contribute to human diseases, including cancer. Mammalian cells repair DSBs mainly through homologous recombination (HR) and nonhomologous end-joining (NHEJ). The choice between these pathways is regulated by t...

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Detalles Bibliográficos
Autores principales: Lee, Doohyung, Apelt, Katja, Lee, Seong-Ok, Chan, Hsin-Ru, Luijsterburg, Martijn S, Leung, Justin W C, Miller, Kyle M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023290/
https://www.ncbi.nlm.nih.gov/pubmed/35253893
http://dx.doi.org/10.1093/nar/gkac160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023290/
https://www.ncbi.nlm.nih.gov/pubmed/35253893
http://dx.doi.org/10.1093/nar/gkac160

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