PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites

Dual-inhibitors of PARP1 and PARP2 are promising anti-cancer drugs. In addition to blocking PARP1&2 enzymatic activity, PARP inhibitors also extend the lifetime of DNA damage-induced PARP1&2 foci, termed trapping. Trapping is important for the therapeutic effects of PARP inhibitors. Using li...

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Detalles Bibliográficos
Autores principales: Lin, Xiaohui, Jiang, Wenxia, Rudolph, Johannes, Lee, Brian J, Luger, Karolin, Zha, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023293/
https://www.ncbi.nlm.nih.gov/pubmed/35349716
http://dx.doi.org/10.1093/nar/gkac188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023293/
https://www.ncbi.nlm.nih.gov/pubmed/35349716
http://dx.doi.org/10.1093/nar/gkac188

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