Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer

Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and metastatic dissemination. Removal of senescent tumor cells (se...

Descripción completa

Detalles Bibliográficos
Autores principales: Troiani, Martina, Colucci, Manuel, D’Ambrosio, Mariantonietta, Guccini, Ilaria, Pasquini, Emiliano, Varesi, Angelica, Valdata, Aurora, Mosole, Simone, Revandkar, Ajinkya, Attanasio, Giuseppe, Rinaldi, Andrea, Rinaldi, Anna, Bolis, Marco, Cippà, Pietro, Alimonti, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023465/
https://www.ncbi.nlm.nih.gov/pubmed/35449130
http://dx.doi.org/10.1038/s41467-022-29824-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023465/
https://www.ncbi.nlm.nih.gov/pubmed/35449130
http://dx.doi.org/10.1038/s41467-022-29824-1

Ejemplares similares