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Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease
Disturbances of circulating amino acids have been demonstrated in patients with Parkinson’s disease (PD). However, there have been no consistent results for branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs), and related factors have not been explored. We aimed to explore plasma BCAA...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023571/ https://www.ncbi.nlm.nih.gov/pubmed/35449203 http://dx.doi.org/10.1038/s41531-022-00312-z |
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author | Zhang, Yi He, Xiaoqin Qian, Yiwei Xu, Shaoqing Mo, Chengjun Yan, Zheng Yang, Xiaodong Xiao, Qin |
author_facet | Zhang, Yi He, Xiaoqin Qian, Yiwei Xu, Shaoqing Mo, Chengjun Yan, Zheng Yang, Xiaodong Xiao, Qin |
author_sort | Zhang, Yi |
collection | PubMed |
description | Disturbances of circulating amino acids have been demonstrated in patients with Parkinson’s disease (PD). However, there have been no consistent results for branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs), and related factors have not been explored. We aimed to explore plasma BCAA and AAA profiles in PD patients, and identify their correlations with clinical characteristics and the gut microbiota. Plasma BCAA (leucine, isoleucine, and valine) and AAA (tyrosine and phenylalanine) levels were measured in 106 PD patients and 114 controls. Fecal samples were collected from PD patients for microbiota sequencing and functional analysis. We found that plasma BCAAs and tyrosine were decreased in PD patients. BCAAs and AAAs were correlated with clinical characteristics and microbial taxa, and, in particular, they were negatively correlated with the Hoehn and Yahr stage. Compared with early PD patients, BCAA and AAA levels were even lower, and microbial composition was altered in advanced PD patients. Predictive functional analysis indicated that predicted genes numbers involved in BCAA biosynthesis were lower in advanced PD patients. What’s more, the fecal abundances of critical genes (ilvB, ilvC, ilvD, and ilvN) involved in BCAA biosynthesis were reduced and fecal BCAA concentrations were lower in advanced PD patients. In conclusion, the disturbances of plasma BCAAs and AAAs in PD patients may be related to the gut microbiota and exacerbated with PD severity. The microbial amino acid metabolism may serve as a potential mechanistic link. |
format | Online Article Text |
id | pubmed-9023571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90235712022-04-28 Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease Zhang, Yi He, Xiaoqin Qian, Yiwei Xu, Shaoqing Mo, Chengjun Yan, Zheng Yang, Xiaodong Xiao, Qin NPJ Parkinsons Dis Article Disturbances of circulating amino acids have been demonstrated in patients with Parkinson’s disease (PD). However, there have been no consistent results for branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs), and related factors have not been explored. We aimed to explore plasma BCAA and AAA profiles in PD patients, and identify their correlations with clinical characteristics and the gut microbiota. Plasma BCAA (leucine, isoleucine, and valine) and AAA (tyrosine and phenylalanine) levels were measured in 106 PD patients and 114 controls. Fecal samples were collected from PD patients for microbiota sequencing and functional analysis. We found that plasma BCAAs and tyrosine were decreased in PD patients. BCAAs and AAAs were correlated with clinical characteristics and microbial taxa, and, in particular, they were negatively correlated with the Hoehn and Yahr stage. Compared with early PD patients, BCAA and AAA levels were even lower, and microbial composition was altered in advanced PD patients. Predictive functional analysis indicated that predicted genes numbers involved in BCAA biosynthesis were lower in advanced PD patients. What’s more, the fecal abundances of critical genes (ilvB, ilvC, ilvD, and ilvN) involved in BCAA biosynthesis were reduced and fecal BCAA concentrations were lower in advanced PD patients. In conclusion, the disturbances of plasma BCAAs and AAAs in PD patients may be related to the gut microbiota and exacerbated with PD severity. The microbial amino acid metabolism may serve as a potential mechanistic link. Nature Publishing Group UK 2022-04-21 /pmc/articles/PMC9023571/ /pubmed/35449203 http://dx.doi.org/10.1038/s41531-022-00312-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Yi He, Xiaoqin Qian, Yiwei Xu, Shaoqing Mo, Chengjun Yan, Zheng Yang, Xiaodong Xiao, Qin Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease |
title | Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease |
title_full | Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease |
title_fullStr | Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease |
title_full_unstemmed | Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease |
title_short | Plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of Parkinson’s disease |
title_sort | plasma branched-chain and aromatic amino acids correlate with the gut microbiota and severity of parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023571/ https://www.ncbi.nlm.nih.gov/pubmed/35449203 http://dx.doi.org/10.1038/s41531-022-00312-z |
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