Mucin-Type O-Glycosylation Proximal to β-Secretase Cleavage Site Affects APP Processing and Aggregation Fate

The amyloid-β precursor protein (APP) undergoes proteolysis by β- and γ-secretases to form amyloid-β peptides (Aβ), which is a hallmark of Alzheimer’s disease (AD). Recent findings suggest a possible role of O-glycosylation on APP’s proteolytic processing and subsequent fate for AD-related pathology...

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Detalles Bibliográficos
Autores principales: Singh, YashoNandini, Regmi, Deepika, Ormaza, David, Ayyalasomayajula, Ramya, Vela, Nancy, Mundim, Gustavo, Du, Deguo, Minond, Dmitriy, Cudic, Maré
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023740/
https://www.ncbi.nlm.nih.gov/pubmed/35464218
http://dx.doi.org/10.3389/fchem.2022.859822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023740/
https://www.ncbi.nlm.nih.gov/pubmed/35464218
http://dx.doi.org/10.3389/fchem.2022.859822

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