The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage

Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenases that utilize a cysteine thiolate–ligated heme moiety to perform a wide range of demanding oxidative transformations. Given the oxidative power of the active intermediate formed within P450s during their active cycle, it is remarkabl...

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Detalles Bibliográficos
Autores principales: Greule, Anja, Izoré, Thierry, Machell, Daniel, Hansen, Mathias H., Schoppet, Melanie, De Voss, James J., Charkoudian, Louise K., Schittenhelm, Ralf B., Harmer, Jeffrey R., Cryle, Max J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023744/
https://www.ncbi.nlm.nih.gov/pubmed/35464232
http://dx.doi.org/10.3389/fchem.2022.868240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023744/
https://www.ncbi.nlm.nih.gov/pubmed/35464232
http://dx.doi.org/10.3389/fchem.2022.868240

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