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The Cytochrome P450 OxyA from the Kistamicin Biosynthesis Cyclization Cascade is Highly Sensitive to Oxidative Damage

Cytochrome P450 enzymes (P450s) are a superfamily of monooxygenases that utilize a cysteine thiolate–ligated heme moiety to perform a wide range of demanding oxidative transformations. Given the oxidative power of the active intermediate formed within P450s during their active cycle, it is remarkabl...

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Detalles Bibliográficos
Autores principales:	Greule, Anja, Izoré, Thierry, Machell, Daniel, Hansen, Mathias H., Schoppet, Melanie, De Voss, James J., Charkoudian, Louise K., Schittenhelm, Ralf B., Harmer, Jeffrey R., Cryle, Max J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023744/ https://www.ncbi.nlm.nih.gov/pubmed/35464232 http://dx.doi.org/10.3389/fchem.2022.868240

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