DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice

DDX41 is a tumor suppressor frequently mutated in human myeloid neoplasms, but whether it affects hematopoiesis is unknown. Using a knockout mouse, we demonstrate that DDX41 is required for mouse hematopoietic stem and progenitor cell (HSPC) survival and differentiation, particularly of myeloid line...

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Detalles Bibliográficos
Autores principales: Ma, Jing, Mahmud, Nadim, Bosland, Maarten C., Ross, Susan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023775/
https://www.ncbi.nlm.nih.gov/pubmed/35303436
http://dx.doi.org/10.1016/j.stemcr.2022.02.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023775/
https://www.ncbi.nlm.nih.gov/pubmed/35303436
http://dx.doi.org/10.1016/j.stemcr.2022.02.010

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