RARG S427L attenuates the DNA repair response to doxorubicin in induced pluripotent stem cell-derived cardiomyocytes

Doxorubicin is a commonly used chemotherapeutic drug, but its use is limited by doxorubicin-induced cardiotoxicity (DIC), which can lead to irreversible heart failure and death. A missense variant rs2229774 (p.S427L) in the retinoic acid receptor gamma (RARG) gene is associated with increased suscep...

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Detalles Bibliográficos
Autores principales: Huang, Haojun, Christidi, Effimia, Shafaattalab, Sanam, Davis, Margot K., Tibbits, Glen F., Brunham, Liam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023798/
https://www.ncbi.nlm.nih.gov/pubmed/35364012
http://dx.doi.org/10.1016/j.stemcr.2022.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023798/
https://www.ncbi.nlm.nih.gov/pubmed/35364012
http://dx.doi.org/10.1016/j.stemcr.2022.03.002

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