Ranolazine rescues the heart failure phenotype of PLN-deficient human pluripotent stem cell-derived cardiomyocytes

Phospholamban (PLN) is a key regulator that controls the function of the sarcoplasmic reticulum (SR) and is required for the regulation of cardiac contractile function. Although PLN-deficient mice demonstrated improved cardiac function, PLN loss in humans can result in dilated cardiomyopathy (DCM) o...

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Detalles Bibliográficos
Autores principales: Jiang, Youxu, Li, Xiaowei, Guo, Tianwei, Lu, Wen-Jing, Ma, Shuhong, Chang, Yun, Song, Yuanxiu, Zhang, Siyao, Bai, Rui, Wang, Hongyue, Qi, Man, Jiang, Hongfeng, Zhang, Hongjia, Lan, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023809/
https://www.ncbi.nlm.nih.gov/pubmed/35334215
http://dx.doi.org/10.1016/j.stemcr.2022.02.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023809/
https://www.ncbi.nlm.nih.gov/pubmed/35334215
http://dx.doi.org/10.1016/j.stemcr.2022.02.016

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