Cargando…

Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging

Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders, including cerebral small vessel disease and Alzheimer’s disease. An emerging biomarker of BBB dysfunction is BBB water exchange rate (k(W)) as measured by diffusion-weighted arterial spin labeling (DW-ASL) MRI....

Descripción completa

Detalles Bibliográficos
Autores principales:	Ford, Jeremy N., Zhang, Qihao, Sweeney, Elizabeth M., Merkler, Alexander E., de Leon, Mony J., Gupta, Ajay, Nguyen, Thanh D., Ivanidze, Jana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024318/ https://www.ncbi.nlm.nih.gov/pubmed/35462701 http://dx.doi.org/10.3389/fnagi.2022.867452

Ejemplares similares

The role of neutrophils in the dysfunction of central nervous system barriers
por: Santos-Lima, Bruno, et al.
Publicado: (2022)

Statistical Parametric Mapping in Amyloid Positron Emission Tomography
por: Smith, Natasha M., et al.
Publicado: (2022)

Characterization of white matter over 1–2 years in small vessel disease using MR-based quantitative susceptibility mapping and free-water mapping
por: Sun, Yawen, et al.
Publicado: (2022)

Severe Hypoglycemia Contributing to Cognitive Dysfunction in Diabetic Mice Is Associated With Pericyte and Blood–Brain Barrier Dysfunction
por: Lin, Lu, et al.
Publicado: (2021)

Phosphate Burden and Organ Dysfunction
por: Mironov, Nikolay, et al.
Publicado: (2022)

Lysosomal dysfunction in diabetic cardiomyopathy
por: Kobayashi, Satoru, et al.
Publicado: (2023)

Quantitative transport mapping (QTM) of the kidney with an approximate microvascular network
por: Zhou, Liangdong, et al.
Publicado: (2020)

Quantitative nanohistology of aging dermal collagen
por: Huang, Sophia, et al.
Publicado: (2023)

Evaluation of quantitative biomarkers of aging in human PBMCs
por: Owen, Brady M., et al.
Publicado: (2023)

Blood-brain barrier dysfunction and Alzheimer’s disease: associations, pathogenic mechanisms, and therapeutic potential
por: Chen, Yanting, et al.
Publicado: (2023)

Proteolysis dysfunction in the process of aging and age-related diseases
por: Frankowska, Natalia, et al.
Publicado: (2022)

Ebselen prevents cigarette smoke-induced gastrointestinal dysfunction in mice
por: Balasuriya, Gayathri K., et al.
Publicado: (2020)

Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity
por: Thomas, Alyssa L., et al.
Publicado: (2021)

Peripheral inflammation promotes brain tau transmission via disrupting blood–brain barrier
por: Liu, Yanchao, et al.
Publicado: (2020)

Sex Differences in Large Artery Stiffness: Implications for Cerebrovascular Dysfunction and Alzheimer’s Disease
por: Kehmeier, Mackenzie N., et al.
Publicado: (2021)

Exploiting the neuroprotective effects of α-klotho to tackle ageing- and neurodegeneration-related cognitive dysfunction
por: Hanson, Kelsey, et al.
Publicado: (2021)

NAD-Linked Metabolism and Intervention in Short Telomere Syndromes and Murine Models of Telomere Dysfunction
por: Stock, Amanda J, et al.
Publicado: (2021)

Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy
por: Collins, Helen E., et al.
Publicado: (2021)

Differential Effects of 2-Deoxyglucose and Glucose Deprivation on 4-Hydroxynonenal Dependent Mitochondrial Dysfunction in Primary Neurons
por: Dodson, Matthew, et al.
Publicado: (2022)

Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults
por: Zhou, Liangdong, et al.
Publicado: (2023)

Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting
por: Wan, Jing, et al.
Publicado: (2020)

Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8(+) EMRA T Cells During Type 2 Diabetes
por: Callender, Lauren A., et al.
Publicado: (2021)

Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans
por: Walsh, Kenneth, et al.
Publicado: (2022)

Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood–brain barrier
por: Kopel, Jonathan J., et al.
Publicado: (2021)

Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction
por: Edling, Charlotte E., et al.
Publicado: (2019)

Alzheimer's disease pathology: pathways between chronic vascular risk factors and blood-brain barrier dysfunction in a cohort of patients with different types of dementia
por: Gan, Jinghuan, et al.
Publicado: (2023)

H(2)O(2) down-regulates SIRT7’s protective role of endothelial premature dysfunction via microRNA-335-5p
por: Liu, Yixin, et al.
Publicado: (2022)

Associations between patterns of physical activity, pain intensity, and interference among older adults with chronic pain: a secondary analysis of two randomized controlled trials
por: Fanning, Jason, et al.
Publicado: (2023)

Multi-omics studies reveal ameliorating effects of physical exercise on neurodegenerative diseases
por: Guo, Yuhuai, et al.
Publicado: (2022)

Telomeres, Atherosclerosis, and Human Longevity: A Causal Hypothesis
por: Aviv, Abraham, et al.
Publicado: (2015)

Editorial: Mitochondrial Dysfunction in Stroke
por: Yan, Feng, et al.
Publicado: (2022)

Role of BAG5 in Protein Quality Control: Double-Edged Sword?
por: Gupta, Manish K., et al.
Publicado: (2022)

Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants
por: Traa, Annika, et al.
Publicado: (2023)

Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice
por: Nan, Xinyu, et al.
Publicado: (2022)

The effects of different types of Tai Chi exercises on motor function in patients with Parkinson's disease: A network meta-analysis
por: Lei, Honghui, et al.
Publicado: (2022)

The FGFR4 Homolog KIN-9 Regulates Lifespan and Stress Responses in Caenorhabditis elegans
por: Mallick, Avijit, et al.
Publicado: (2022)

C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration
por: Naranjo-Galindo, Francisco José, et al.
Publicado: (2022)

Highlighting the value of Alzheimer’s disease-focused registries: lessons learned from cancer surveillance
por: Miller, Margaret C., et al.
Publicado: (2023)

Imaging blood–brain barrier disruption in neuroinflammation and Alzheimer’s disease
por: Lee, Rae-Ling, et al.
Publicado: (2023)

Utility of quantitative MRI metrics in brain ageing research
por: Filip, Pavel, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j0i2d8v845q9bch649s99nm8k2